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STIM1


Official Full Name
stromal interaction molecule 1
Organism
Homo sapiens
Gene ID
6786
Background
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Synonyms
GOK; TAM; TAM1; IMD10; STRMK; D11S4896E

Cat.No. Product Name Price
SHW001476 shRNA set against Chicken STIM1 (NM_001030838) Inquiry
SHH419640 shRNA set against Human STIM1 (NM_003156.3) Inquiry
SHH419644 shRNA set against Mouse STIM1 (NM_009287.4) Inquiry
SHH419648 shRNA set against Rat STIM1 (NM_001108496.2) Inquiry
SHL033876 shRNA set against Mouse Stim1(NM_009287.4) Inquiry
Cat.No. Product Name Price
CDCL186327 Mouse STIM1 ORF clone(NM_009287.4) Inquiry
CDFR008108 Rat Stim1 cDNA Clone(NM_001108496.2) Inquiry
MiUTR1M-11329 STIM1 miRNA 3'UTR clone Inquiry
MiUTR1R-07748 STIM1 miRNA 3'UTR clone Inquiry
MiUTR3H-08048 STIM1 miRNA 3'UTR clone Inquiry
CDCB162951 Chicken STIM1 ORF Clone (NM_001030838) Inquiry
CDCB190441 Rabbit STIM1 ORF clone (XM_008264878.1) Inquiry
CDCL186326 Human STIM1 ORF clone(NM_003156.3) Inquiry
CDCR375149 Rat Stim1 ORF Clone(NM_001108496.2) Inquiry
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