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STAT2

Official Full Name
signal transducer and activator of transcription 2, 113kDa
Background
STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells,Is critical to the transcriptional responses induced by type I interferons,ifN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by ifN-alpha/beta via assocations with receptor-bound Jak kinases.
Synonyms
STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816; wu:fj84d07; fj84d07

Cat.No. Product Name Price
CLKO-1625STAT2 KO Cell Lysate-HeLaInquiry

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