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SRCAP

Official Full Name
Snf2 related CREBBP activator protein
Organism
Homo sapiens
GeneID
10847
Background
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Synonyms
EAF1; FLHS; SWR1; DOMO1; DEHMBA;

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