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SPTLC2

Official Full Name
serine palmitoyltransferase long chain base subunit 2
Organism
Homo sapiens
GeneID
9517
Background
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]
Synonyms
LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a;

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