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SPAST


Official Full Name
spastin
Organism
Homo sapiens
Gene ID
6683
Background
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The use of alternative translational initiation sites in this gene results in a single transcript variant that can produce isoforms that differ in the length of their N-terminus and which thereby differ in the efficiency of their export from the nucleus to the cytoplasm. In addition, alternative splicing results in multiple transcript variants that encode isoforms that differ in other protein regions as well. One isoform of this gene has been shown to be a microtubule-severing enzyme that regulates microtubule abundance, mobility, and plus-end distribution. Mutations in this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, May 2018]
Synonyms
FSP2; SPG4; ADPSP

Cat.No. Product Name Price
SHH415996 shRNA set against Human Spast (NM_199436.1) Inquiry
SHH416000 shRNA set against Mouse Spast (NM_016962.2) Inquiry
SHH416004 shRNA set against Rat Spast (NM_001108702.2) Inquiry
SHL026378 shRNA set against Human SPAST(NM_014946.3) Inquiry
SHL026414 shRNA set against Human SPAST(NM_199436.1) Inquiry
SHW001683 shRNA set against Chicken SPAST (NM_001031061) Inquiry
SHW018054 shRNA set against Danio rerio SPAST (NM_212915) Inquiry
Cat.No. Product Name Price
CDCB179529 Danio rerio SPAST ORF Clone (NM_212915) Inquiry
CDCH084942 human SPAST ORF clone (NM_199436.1) Inquiry
CDCR298608 Human SPAST ORF Clone(NM_014946.3) Inquiry
CDFG013139 Human SPAST cDNA Clone(NM_199436.1) Inquiry
CDFH018428 Human SPAST cDNA Clone(NM_014946.3) Inquiry
CDFR008291 Rat Spast cDNA Clone(NM_001108702.2) Inquiry
MiUTR1H-09812 SPAST miRNA 3'UTR clone Inquiry
MiUTR1H-09813 SPAST miRNA 3'UTR clone Inquiry
CDCB163158 Chicken SPAST ORF Clone (NM_001031061) Inquiry
CDCB190247 Rabbit SPAST ORF clone (XM_008254733.1) Inquiry
CDCH084946 Mouse Spast ORF clone (NM_001162870.1) Inquiry
CDCR253325 Mouse Spast ORF Clone(NM_016962.2) Inquiry
CDCR375224 Rat Spast ORF Clone(NM_001108702.2) Inquiry
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