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SPAM1


Official Full Name
sperm adhesion molecule 1
Organism
Homo sapiens
Gene ID
6677
Background
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Synonyms
HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n

Cat.No. Product Name Price
SHH415912 shRNA set against Human SPAM1 (NM_003117.4) Inquiry
SHH415916 shRNA set against Mouse SPAM1 (NM_009241.2) Inquiry
SHH415920 shRNA set against Rat SPAM1 (NM_053967.2) Inquiry
SHL025984 shRNA set against Mouse Spam1(NM_001079875.1) Inquiry
SHL026038 shRNA set against Mouse Spam1(NM_009241.2) Inquiry
SHW011042 shRNA set against Danio rerio SPAM1 (NM_001080685) Inquiry
Cat.No. Product Name Price
CDCB195502 Rabbit SPAM1 ORF clone (XM_008258249.1) Inquiry
CDCS409050 Human SPAM1 ORF Clone (BC026163) Inquiry
CDFH018415 Human SPAM1 cDNA Clone(NM_001174044.1) Inquiry
CDFH018416 Human SPAM1 cDNA Clone(NM_001174045.1) Inquiry
CDFH018417 Human SPAM1 cDNA Clone(NM_001174046.1) Inquiry
CDFL012907 Mouse Spam1 cDNA Clone(NM_009241.2) Inquiry
MiUTR1M-11127 SPAM1 miRNA 3'UTR clone Inquiry
MiUTR1M-11128 SPAM1 miRNA 3'UTR clone Inquiry
CDCB172517 Danio rerio SPAM1 ORF Clone (NM_001080685) Inquiry
CDCH084908 Mouse Spam1 ORF clone (NM_001079875.1) Inquiry
CDCR246829 Mouse Spam1 ORF Clone(NM_009241.2) Inquiry
CDCR356884 Human SPAM1 ORF Clone(NM_001174044.1) Inquiry
CDCR356887 Human SPAM1 ORF Clone(NM_001174045.1) Inquiry
CDCR356888 Human SPAM1 ORF Clone(NM_001174046.1) Inquiry
CDCR380676 Rat Spam1 ORF Clone(NM_053967.2) Inquiry
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