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SORCS3


Official Full Name
sortilin related VPS10 domain containing receptor 3
Organism
Homo sapiens
Gene ID
22986
Background
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]
Synonyms
SORCS

Cat.No. Product Name Price
SHH415164 shRNA set against Human SORCS3 (NM_014978.1) Inquiry
SHH415168 shRNA set against Mouse SORCS3 (NM_025696.3) Inquiry
SHH415172 shRNA set against Rat SORCS3 (NM_001106367.3) Inquiry
SHL016698 shRNA set against Human SORCS3(NM_014978.1) Inquiry
SHL016752 shRNA set against Mouse Sorcs3(NM_025696.3) Inquiry
Cat.No. Product Name Price
CDFH018348 Human SORCS3 cDNA Clone(NM_014978.1) Inquiry
CDFL012856 Mouse Sorcs3 cDNA Clone(NM_025696.3) Inquiry
MiUTR1H-09753 SORCS3 miRNA 3'UTR clone Inquiry
MiUTR1M-11092 SORCS3 miRNA 3'UTR clone Inquiry
CDCB187588 Rabbit SORCS3 ORF clone (XM_008270491.1) Inquiry
CDCH084518 human SORCS3 ORF clone (NM_014978.1) Inquiry
CDCH084520 Mouse Sorcs3 ORF clone (NM_025696.3) Inquiry
CDCR373169 Rat Sorcs3 ORF Clone(NM_001106367.3) Inquiry
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