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SMPD4

Official Full Name
sphingomyelin phosphodiesterase 4
Organism
Homo sapiens
GeneID
55627
Background
The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]
Synonyms
SKNY; NET13; NEDMABA; NEDMEBA; NSMASE3; NSMASE-3;

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