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SMC1A


Official Full Name
structural maintenance of chromosomes 1A
Organism
Homo sapiens
Gene ID
8243
Background
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Synonyms
SMC1; SMCB; CDLS2; DEE85; SB1.8; EIEE85; SMC1L1; DXS423E; SMC1alpha

Cat.No. Product Name Price
SHH413232 shRNA set against Mouse Smc1a (NM_019710.2) Inquiry
SHH413236 shRNA set against Rat Smc1a (NM_031683.1) Inquiry
SHL016266 shRNA set against Human SMC1A(NM_006306.2) Inquiry
SHW005028 shRNA set against Chicken SMC1A (NM_204516) Inquiry
SHW013403 shRNA set against Danio rerio SMC1A (NM_001161631) Inquiry
Cat.No. Product Name Price
CDCR254225 Mouse Smc1a ORF Clone(NM_019710.2) Inquiry
CDFH018164 Human SMC1A cDNA Clone(NM_006306.2) Inquiry
CDFR012819 Rat Smc1a cDNA Clone(NM_031683.1) Inquiry
MiUTR1H-09652 SMC1A miRNA 3'UTR clone Inquiry
MiUTR1R-07562 SMC1A miRNA 3'UTR clone Inquiry
CDCB166503 Chicken SMC1A ORF Clone (NM_204516) Inquiry
CDCB174878 Danio rerio SMC1A ORF Clone (NM_001161631) Inquiry
CDCB188400 Rabbit SMC1A ORF clone (XM_008272656.1) Inquiry
CDCR292541 Human SMC1A ORF Clone(NM_006306.2) Inquiry
CDCR379833 Rat Smc1a ORF Clone(NM_031683.1) Inquiry
CDCS412657 Human SMC1A ORF Clone (BC112127) Inquiry
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