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SLC12A1


Official Full Name
solute carrier family 12 member 1
Organism
Homo sapiens
Gene ID
6557
Background
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
Synonyms
BSC; BSC1; CCC2; BSC-1; NKCC2

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SHH408300 shRNA set against Human Slc12a1 (NM_000338.2) Inquiry
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SHR228066 shRNA set against Human SLC12A1(NM_000338.2) Inquiry
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Cat.No. Product Name Price
CDCH080752 Mouse Slc12a1 ORF clone (NM_001079690.1) Inquiry
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MiUTR1H-09431 SLC12A1 miRNA 3'UTR clone Inquiry
MiUTR1M-10742 SLC12A1 miRNA 3'UTR clone Inquiry
MiUTR1M-10743 SLC12A1 miRNA 3'UTR clone Inquiry
CDCB180558 Rabbit SLC12A1 ORF clone (NM_001170971.1) Inquiry
CDCH080746 human SLC12A1 ORF clone (NM_000338.2) Inquiry
CDCR276070 Mouse Slc12a1 ORF Clone(NM_183354.2) Inquiry
CDCR357589 Human SLC12A1 ORF Clone(NM_001184832.1) Inquiry
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