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SFTPB


Official Full Name
surfactant protein B
Organism
Homo sapiens
Gene ID
6439
Background
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
Synonyms
SP-B; PSP-B; SFTB3; SFTP3; SMDP1

Cat.No. Product Name Price
SHH406064 shRNA set against Human SFTPB (NM_000542.3) Inquiry
SHH406068 shRNA set against Mouse SFTPB (NM_147779.1) Inquiry
SHR220839 shRNA set against Mouse Sftpb(NM_147779.1) Inquiry
SHR220866 shRNA set against Rat Sftpb(NM_138842.1) Inquiry
Cat.No. Product Name Price
CDFL012215 Mouse Sftpb cDNA Clone(NM_147779.1) Inquiry
CDFR014269 Rat Sftpb cDNA Clone(NM_138842.1) Inquiry
MiUTR1M-10641 SFTPB miRNA 3'UTR clone Inquiry
MiUTR1R-07310 SFTPB miRNA 3'UTR clone Inquiry
MiUTR4H-TG08000 SFTPB miRNA 3'UTR clone Inquiry
CDCB180278 Rabbit SFTPB ORF clone (XM_008252614.1) Inquiry
CDCH079402 human SFTPB ORF clone (NM_000542.3) Inquiry
CDCH079406 Mouse Sftpb ORF clone (NM_147779.1) Inquiry
CDCR381316 Rat Sftpb ORF Clone(NM_138842.1) Inquiry
CDCS405731 Human SFTPB ORF Clone (BC032785) Inquiry
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