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SEPP1


Official Full Name
selenoprotein P
Organism
Homo sapiens
Gene ID
6414
Background
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
Synonyms
SELENOP; SeP; SELP; SEPP; SEPP1

Cat.No. Product Name Price
SHG011635 shRNA set against Human SEPP1(NM_005410.2) Inquiry
SHH404584 shRNA set against Human SEPP1 (NM_005410.2) Inquiry
SHH404588 shRNA set against Mouse SEPP1 (NM_009155.3) Inquiry
SHH404592 shRNA set against Rat SEPP1 (NM_019192.2) Inquiry
SHR213194 shRNA set against Mouse Sepp1(NM_001042614.1) Inquiry
SHR213212 shRNA set against Mouse Sepp1(NM_001042613.1) Inquiry
SHR213230 shRNA set against Mouse Sepp1(NM_009155.3) Inquiry
SHR214994 shRNA set against Rat Sepp1(NM_019192.2) Inquiry
SHR215094 shRNA set against Rat Sepp1(NM_001083911.1) Inquiry
SHR215112 shRNA set against Rat Sepp1(NM_019192.2) Inquiry
SHW002189 shRNA set against Chicken SEPP1 (NM_001031609) Inquiry
Cat.No. Product Name Price
CDFH017198 Human SEPP1 cDNA Clone(NM_001085486.1) Inquiry
MiUTR1R-07262 SEPP1 miRNA 3'UTR clone Inquiry
MiUTR1R-07261 SEPP1 miRNA 3'UTR clone Inquiry
MiUTR1M-10556 SEPP1 miRNA 3'UTR clone Inquiry
MiUTR1M-10555 SEPP1 miRNA 3'UTR clone Inquiry
MiUTR1M-10554 SEPP1 miRNA 3'UTR clone Inquiry
MiUTR1H-09272 SEPP1 miRNA 3'UTR clone Inquiry
CDFR011490 Rat Sepp1 cDNA Clone(NM_019192.2) Inquiry
CDFH017200 Human SEPP1 cDNA Clone(NM_005410.2) Inquiry
CDFH017199 Human SEPP1 cDNA Clone(NM_001093726.1) Inquiry
MiUTR3H-04146 SEPP1 miRNA 3'UTR clone Inquiry
CDCR290398 Human SEPP1 ORF Clone(NM_005410.2) Inquiry
MiUTR3H-04145 SEPP1 miRNA 3'UTR clone Inquiry
CDCS407383 Human SEPP1 ORF Clone (BC058919) Inquiry
CDCR378523 Rat Sepp1 ORF Clone(NM_019192.2) Inquiry
CDCR233660 Mouse Sepp1 ORF Clone(NM_001042614.1) Inquiry
CDCR020878 Human SEPP1 ORF clone (NM_001085486.1) Inquiry
CDCR020876 Human SEPP1 ORF clone (NM_001093726.1) Inquiry
CDCH078172 Mouse Sepp1 ORF clone (NM_001042613.1) Inquiry
CDCB182719 Rabbit SEPP1 ORF clone (NM_001199846.1) Inquiry
CDCB163664 Chicken SEPP1 ORF Clone (NM_001031609) Inquiry
CDCB159710 Human SEPP1 ORF clone (BC058919) Inquiry
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