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sec61al2


Official Full Name
SEC61 translocon subunit alpha 1b
Organism
Danio rerio
Gene ID
266796
Background
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Acts upstream of or within pronephros development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including EVL; anterior axial hypoblast; axis; ectoderm; and mesoderm. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
cb413; sec61b; sec61a1l; sec61al2; wu:fb36f05; wu:fb36f12; wu:fb37d04; wu:fi26f11

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SHW017445 shRNA set against Danio rerio SEC61AL2 (NM_201577) Inquiry
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