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SDHB


Official Full Name
succinate dehydrogenase complex iron sulfur subunit B
Organism
Homo sapiens
Gene ID
6390
Background
This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency. [provided by RefSeq, Jun 2022]
Synonyms
IP; SDH; CWS2; PGL4; SDH1; SDH2; PPGL4; SDHIP; MC2DN4

Cat.No. Product Name Price
SHH403416 shRNA set against Human SDHB (NM_003000.2) Inquiry
SHH403420 shRNA set against Mouse SDHB (NM_023374.3) Inquiry
SHH403424 shRNA set against Rat SDHB (NM_001100539.1) Inquiry
SHR192102 shRNA set against Human SDHB(NM_003000.2) Inquiry
SHR192180 shRNA set against Mouse Sdhb(NM_023374.3) Inquiry
SHW002574 shRNA set against Chicken SDHB (NM_001080875) Inquiry
SHW004264 shRNA set against Chicken SDHB (NM_001278039) Inquiry
SHW011589 shRNA set against Danio rerio SDHB (NM_001098740) Inquiry
Cat.No. Product Name Price
CDFH017089 Human SDHB cDNA Clone(NM_003000.2) Inquiry
CDFR005094 Rat Sdhb cDNA Clone(NM_001100539.1) Inquiry
MiUTR1H-09216 SDHB miRNA 3'UTR clone Inquiry
MiUTR1M-10491 SDHB miRNA 3'UTR clone Inquiry
CDCB164049 Chicken SDHB ORF Clone (NM_001080875) Inquiry
CDCB165739 Chicken SDHB ORF Clone (NM_001278039) Inquiry
CDCB173064 Danio rerio SDHB ORF Clone (NM_001098740) Inquiry
CDCB181239 Rabbit SDHB ORF clone (XM_002723860.2) Inquiry
CDCH077802 Mouse Sdhb ORF clone (NM_023374.3) Inquiry
CDCR284649 Human SDHB ORF Clone(NM_003000.2) Inquiry
CDCR372314 Rat Sdhb ORF Clone(NM_001100539.1) Inquiry
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