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RNF12

Official Full Name
ring finger protein, LIM domain interacting
Organism
Homo sapiens
GeneID
51132
Background
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Synonyms
RLIM; MRX61; RNF12; TOKAS; NY-REN-43;

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