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RPA2


Official Full Name
replication protein A2
Organism
Homo sapiens
Gene ID
6118
Background
This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]
Synonyms
REPA2; RPA32; RP-A p32; RP-A p34

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SHH379340 shRNA set against Rat POLR1B (NM_031773.1) Inquiry
SHH397860 shRNA set against Human RPA2 (NM_002946.3) Inquiry
SHH397864 shRNA set against Mouse RPA2 (NM_011284.3) Inquiry
SHH397868 shRNA set against Rat RPA2 (NM_021582.1) Inquiry
SHR187536 shRNA set against Rat Rpa2(NM_021582.1) Inquiry
SHR187634 shRNA set against Mouse Rpa2(NM_011284.3) Inquiry
SHR187698 shRNA set against Rat Rpo1-2(NM_031773.1) Inquiry
SHR187734 shRNA set against Human RPA2(NM_002946.3) Inquiry
SHW001523 shRNA set against Chicken RPA2 (NM_001030892) Inquiry
SHW015119 shRNA set against Danio rerio RPA2 (NM_131711) Inquiry
SHW016697 shRNA set against Danio rerio POLR1B (NM_200518) Inquiry
Cat.No. Product Name Price
CDCS411058 Human RPA2 ORF Clone (BC001630) Inquiry
MiUTR1R-07058 POLR1B miRNA 3'UTR clone Inquiry
MiUTR1R-07023 RPA2 miRNA 3'UTR clone Inquiry
MiUTR1M-10229 RPA2 miRNA 3'UTR clone Inquiry
MiUTR1H-08963 RPA2 miRNA 3'UTR clone Inquiry
CDFR012905 Rat Polr1b cDNA Clone(NM_031773.1) Inquiry
CDFR011691 Rat Rpa2 cDNA Clone(NM_021582.1) Inquiry
CDFH016499 Human RPA2 cDNA Clone(NM_002946.3) Inquiry
CDFH016498 Human RPA2 cDNA Clone(NM_002946.3) Inquiry
CDFH014684 Human POLR1B cDNA Clone(NM_001137604.1) Inquiry
MiUTR3H-04587 POLR1B miRNA 3'UTR clone Inquiry
MiUTR3H-04588 POLR1B miRNA 3'UTR clone Inquiry
CDCR379919 Rat Polr1b ORF Clone(NM_031773.1) Inquiry
CDCR378738 Rat Rpa2 ORF Clone(NM_021582.1) Inquiry
CDCR284482 Human RPA2 ORF Clone(NM_002946.3) Inquiry
CDCH074990 Mouse Rpa2 ORF clone (NM_011284.3) Inquiry
CDCH065858 human POLR1B ORF clone (NM_001137604.1) Inquiry
CDCB189277 Rabbit RPA2 ORF clone (XM_008253269.1) Inquiry
CDCB184722 Rabbit POLR1B ORF clone (XM_002709591.2) Inquiry
CDCB178172 Danio rerio POLR1B ORF Clone (NM_200518) Inquiry
CDCB176594 Danio rerio RPA2 ORF Clone (NM_131711) Inquiry
CDCR382864 Mouse Polr1b ORF Clone(NM_009086.2) Inquiry
CDCB162998 Chicken RPA2 ORF Clone (NM_001030892) Inquiry
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