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RAN


Official Full Name
RAN, member RAS oncogene family
Organism
Homo sapiens
Gene ID
5901
Background
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Synonyms
TC4; Gsp1; ARA24

Cat.No. Product Name Price
LV23468L human RAN (NM_006325) lentivirus particles Inquiry
Cat.No. Product Name Price
SHH389440 shRNA set against Mouse RAN (NM_009391.3) Inquiry
SHH389444 shRNA set against Rat RAN (NM_053439.1) Inquiry
SHR163662 shRNA set against Rat Ran(NM_053439.1) Inquiry
SHR163698 shRNA set against Mouse Ran(NM_009391.3) Inquiry
SHW005753 shRNA set against Chicken RAN (NM_205258) Inquiry
SHW014782 shRNA set against Danio rerio RAN (NM_131309) Inquiry
Cat.No. Product Name Price
CDCS412668 Human RAN ORF Clone (BC014518) Inquiry
MiUTR1M-09910 RAN miRNA 3'UTR clone Inquiry
MiUTR1R-06308 RAN miRNA 3'UTR clone Inquiry
MiUTR3H-03930 RAN miRNA 3'UTR clone Inquiry
CDCB156246 Cynomolgus RAN ORF clone Inquiry
CDCB156452 Rat RAN ORF clone (NM_053439.1) Inquiry
CDCB159469 Human RAN ORF clone (BC014518) Inquiry
CDCB167228 Chicken RAN ORF Clone (NM_205258) Inquiry
CDCB176257 Danio rerio RAN ORF Clone (NM_131309) Inquiry
CDCB186489 Rabbit RAN ORF clone (XM_008250415.1) Inquiry
CDCH071454 Mouse Ran ORF clone (NM_009391.3) Inquiry
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