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RAG2


Official Full Name
recombination activating 2
Organism
Homo sapiens
Gene ID
5897
Background
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
Synonyms
RAG-2

Cat.No. Product Name Price
SHH389228 shRNA set against Human RAG2 (NM_000536.3) Inquiry
SHH389232 shRNA set against Mouse RAG2 (NM_009020.3) Inquiry
SHR162804 shRNA set against Mouse Rag2(NM_009020.3) Inquiry
SHW014847 shRNA set against Danio rerio RAG2 (NM_131385) Inquiry
Cat.No. Product Name Price
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CDCB176322 Danio rerio RAG2 ORF Clone (NM_131385) Inquiry
CDCB180350 Rabbit RAG2 ORF clone (XM_008268593.1) Inquiry
CDCH396307 Rat RAG2 ORF clone(NM_001100528.1) Inquiry
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