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PTRF


Official Full Name
caveolae associated protein 1
Organism
Homo sapiens
Gene ID
284119
Background
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
Synonyms
CAVIN1; CGL4; PTRF; CAVIN; FKSG13; cavin-1

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SHH386900 shRNA set against Human PTRF (NM_012232.5) Inquiry
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SHR154262 shRNA set against Mouse Ptrf(NM_008986.2) Inquiry
SHW000056 shRNA set against Chicken PTRF (NM_001001471) Inquiry
Cat.No. Product Name Price
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CDCB161531 Chicken PTRF ORF Clone (NM_001001471) Inquiry
CDCB181376 Rabbit PTRF ORF clone (XM_008271506.1) Inquiry
CDCH070034 Mouse Ptrf ORF clone (NM_008986.2) Inquiry
CDCR372659 Rat Ptrf ORF Clone(NM_001105841.1) Inquiry
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