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PTPN22

Official Full Name
protein tyrosine phosphatase non-receptor type 22
Organism
Homo sapiens
GeneID
26191
Background
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Synonyms
LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6;

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