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PTPN12


Official Full Name
protein tyrosine phosphatase non-receptor type 12
Organism
Homo sapiens
Gene ID
5782
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Synonyms
PTPG1; PTP-PEST

Cat.No. Product Name Price
SHH386448 shRNA set against Mouse PTPN12 (NM_011203.2) Inquiry
SHH386444 shRNA set against Human PTPN12 (NM_002835.3) Inquiry
SHH386452 shRNA set against Rat PTPN12 (NM_057115.2) Inquiry
SHR151824 shRNA set against Rat Ptpn12(NM_057115.2) Inquiry
SHR151906 shRNA set against Mouse Ptpn12(NM_011203.2) Inquiry
SHW016824 shRNA set against Danio rerio PTPN12 (NM_200669) Inquiry
Cat.No. Product Name Price
CDFH015515 Human PTPN12 cDNA Clone(NM_001131008.1) Inquiry
CDFH015516 Human PTPN12 cDNA Clone(NM_001131009.1) Inquiry
CDFR013727 Rat Ptpn12 cDNA Clone(NM_057115.2) Inquiry
MiUTR1M-09755 PTPN12 miRNA 3'UTR clone Inquiry
MiUTR1R-06197 PTPN12 miRNA 3'UTR clone Inquiry
MiUTR3H-03129 PTPN12 miRNA 3'UTR clone Inquiry
MiUTR3H-03130 PTPN12 miRNA 3'UTR clone Inquiry
MiUTR3H-03131 PTPN12 miRNA 3'UTR clone Inquiry
CDCB178299 Danio rerio PTPN12 ORF Clone (NM_200669) Inquiry
CDCB187392 Rabbit PTPN12 ORF clone (XM_008258311.1) Inquiry
CDCH069682 human PTPN12 ORF clone (NM_001131008.1) Inquiry
CDCH069684 human PTPN12 ORF clone (NM_001131009.1) Inquiry
CDCH069686 Mouse Ptpn12 ORF clone (NM_011203.2) Inquiry
CDCL185905 Human PTPN12 ORF clone(NM_002835.3) Inquiry
CDCR380760 Rat Ptpn12 ORF Clone(NM_057115.2) Inquiry
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