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PSMC5


Official Full Name
proteasome 26S subunit, ATPase 5
Organism
Homo sapiens
Gene ID
5705
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Synonyms
S8; p45; RPT6; SUG1; SUG-1; TBP10; TRIP1; p45/SUG

Cat.No. Product Name Price
SHH385324 shRNA set against Human PSMC5 (NM_002805.5) Inquiry
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SHH385332 shRNA set against Rat PSMC5 (NM_031149.1) Inquiry
SHR147948 shRNA set against Rat Psmc5(NM_031149.1) Inquiry
SHR148020 shRNA set against Mouse Psmc5(NM_008950.1) Inquiry
SHW004457 shRNA set against Chicken PSMC5 (NM_001292069) Inquiry
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Cat.No. Product Name Price
CDCS409434 Human PSMC5 ORF Clone (BC001932) Inquiry
CDFL010962 Mouse Psmc5 cDNA Clone(NM_008950.1) Inquiry
CDFR012608 Rat Psmc5 cDNA Clone(NM_031149.1) Inquiry
MiUTR1M-09695 PSMC5 miRNA 3'UTR clone Inquiry
MiUTR1R-06151 PSMC5 miRNA 3'UTR clone Inquiry
MiUTR3H-04317 PSMC5 miRNA 3'UTR clone Inquiry
CDCB158805 Human PSMC5 ORF clone (BC001932) Inquiry
CDCB165932 Chicken PSMC5 ORF Clone (NM_001292069) Inquiry
CDCB168441 Danio rerio PSMC5 ORF Clone (NM_001003740) Inquiry
CDCB188003 Rabbit PSMC5 ORF clone (XM_002719477.2) Inquiry
CDCH069090 human PSMC5 ORF clone (NM_001199163.1) Inquiry
CDCH069092 Mouse Psmc5 ORF clone (NM_008950.1) Inquiry
CDCR379641 Rat Psmc5 ORF Clone(NM_031149.1) Inquiry
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