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PSMC3


Official Full Name
proteasome 26S subunit, ATPase 3
Organism
Homo sapiens
Gene ID
5702
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
Synonyms
RPT5; TBP1; DCIDP

Cat.No. Product Name Price
SHH385288 shRNA set against Human PSMC3 (NM_002804.4) Inquiry
SHH385292 shRNA set against Mouse PSMC3 (NM_008948.2) Inquiry
SHH385296 shRNA set against Rat PSMC3 (NM_031595.1) Inquiry
SHR147894 shRNA set against Human PSMC3(NM_002804.4) Inquiry
SHR147930 shRNA set against Rat Psmc3(NM_031595.1) Inquiry
SHW001796 shRNA set against Chicken PSMC3 (NM_001031190) Inquiry
SHW006184 shRNA set against Danio rerio PSMC3 (NM_001002064) Inquiry
Cat.No. Product Name Price
CDFH015377 Human PSMC3 cDNA Clone(NM_002804.4) Inquiry
CDFR012751 Rat Psmc3 cDNA Clone(NM_031595.1) Inquiry
MiUTR1H-08385 PSMC3 miRNA 3'UTR clone Inquiry
MiUTR1R-06148 PSMC3 miRNA 3'UTR clone Inquiry
CDCB156366 Rat PSMC3 ORF clone (BC062019.1) Inquiry
CDCB157908 Human PSMC3 ORF clone (BC073165) Inquiry
CDCB163271 Chicken PSMC3 ORF Clone (NM_001031190) Inquiry
CDCB167659 Danio rerio PSMC3 ORF Clone (NM_001002064) Inquiry
CDCB185533 Rabbit PSMC3 ORF clone (XM_002709095.2) Inquiry
CDCH395672 Mouse PSMC3 ORF clone(NM_008948.2) Inquiry
CDCR284103 Human PSMC3 ORF Clone(NM_002804.4) Inquiry
CDCR379614 Rat Psmc3 ORF Clone(NM_031595.1) Inquiry
CDCS410973 Human PSMC3 ORF Clone (BC073165) Inquiry
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