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PSMB8


Official Full Name
proteasome 20S subunit beta 8
Organism
Homo sapiens
Gene ID
5696
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]
Synonyms
JMP; ALDD; LMP7; NKJO; D6S216; PRAAS1; PSMB5i; RING10; D6S216E

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CDFG009233 Human PSMB8 cDNA Clone(NM_148919.3) Inquiry
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CDFR013830 Rat Psmb8 cDNA Clone(NM_080767.2) Inquiry
MiUTR1H-08381 PSMB8 miRNA 3'UTR clone Inquiry
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MiUTR1M-09690 PSMB8 miRNA 3'UTR clone Inquiry
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