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PLCE1


Official Full Name
phospholipase C epsilon 1
Organism
Homo sapiens
Gene ID
51196
Background
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Synonyms
PLCE; PPLC; NPHS3

Cat.No. Product Name Price
SHH377209 shRNA set against Mouse PLCE1 (NM_019588.2) Inquiry
SHH377204 shRNA set against Human PLCE1 (NM_016341.3) Inquiry
SHH377212 shRNA set against Rat PLCE1 (NM_053758.2) Inquiry
SHR120678 shRNA set against Mouse Plce1(NM_019588.2) Inquiry
SHR120732 shRNA set against Human PLCE1(NM_016341.3) Inquiry
SHW013405 shRNA set against Danio rerio PLCE1 (NM_001161653) Inquiry
Cat.No. Product Name Price
CDCG002389 Human PLCE1 ORF clone(NM_016341.3) Inquiry
CDCR254081 Mouse Plce1 ORF Clone(NM_019588.2) Inquiry
CDFH014462 Human PLCE1 cDNA Clone(NM_001165979.1) Inquiry
MiUTR1H-07980 PLCE1 miRNA 3'UTR clone Inquiry
MiUTR1M-09304 PLCE1 miRNA 3'UTR clone Inquiry
MiUTR3H-09982 PLCE1 miRNA 3'UTR clone Inquiry
CDCB174880 Danio rerio PLCE1 ORF Clone (NM_001161653) Inquiry
CDCB191040 Rabbit PLCE1 ORF clone (XM_008270223.1) Inquiry
CDCH064668 human PLCE1 ORF clone (NM_001165979.1) Inquiry
CDCR380538 Rat Plce1 ORF Clone(NM_053758.2) Inquiry
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