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PEG10


Official Full Name
paternally expressed 10
Organism
Homo sapiens
Gene ID
23089
Background
This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
Synonyms
EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1

Cat.No. Product Name Price
SHH373404 shRNA set against Human PEG10 (NM_001040152.1) Inquiry
SHH373408 shRNA set against Mouse PEG10 (NM_130877.2) Inquiry
SHR103908 shRNA set against Human PEG10(NM_015068.3) Inquiry
SHR103944 shRNA set against Human PEG10(NM_001040152.1) Inquiry
SHR103962 shRNA set against Mouse Peg10(NM_130877.2) Inquiry
SHR103980 shRNA set against Mouse Peg10(NM_001040611.1) Inquiry
Cat.No. Product Name Price
MiUTR1M-09099 PEG10 miRNA 3'UTR clone Inquiry
MiUTR1H-07776 PEG10 miRNA 3'UTR clone Inquiry
MiUTR1H-07775 PEG10 miRNA 3'UTR clone Inquiry
CDFL010131 Mouse Peg10 cDNA Clone(NM_130877.2) Inquiry
CDCL147987 Mouse Peg10 ORF clone (NM_130877.2) Inquiry
CDFH014052 Human PEG10 cDNA Clone(NM_015068.3) Inquiry
CDCR344071 Human PEG10 ORF Clone(NM_001040152.1) Inquiry
CDFH014050 Human PEG10 cDNA Clone(NM_001184962.1) Inquiry
CDFH014049 Human PEG10 cDNA Clone(NM_001172438.1) Inquiry
MiUTR1M-09098 PEG10 miRNA 3'UTR clone Inquiry
CDFH014048 Human PEG10 cDNA Clone(NM_001040152.1) Inquiry
CDCS407022 Human PEG10 ORF Clone (BC050659) Inquiry
CDCR357687 Human PEG10 ORF Clone(NM_001184961.1) Inquiry
CDCL147989 Human Peg10 ORF clone (NM_001040611.1) Inquiry
CDCL147985 Mouse PEG10 ORF clone (NM_001172438.1) Inquiry
CDCL147983 Mouse PEG10 ORF clone (NM_001172437.1) Inquiry
CDCL147981 Human PEG10 ORF clone (NM_015068.3) Inquiry
CDCR357690 Human PEG10 ORF Clone(NM_001184962.1) Inquiry
CDCB181127 Rabbit PEG10 ORF clone (NM_001292089.2) Inquiry
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