Pages
Products

Pea15a


Official Full Name
proliferation and apoptosis adaptor protein 15A
Organism
Mus musculus
Gene ID
18611
Background
This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Synonyms
Pea15a; Mat1; Pea15; PEA-15; Pkcs15

Cat.No. Product Name Price
SHH373320 shRNA set against Mouse Pea15a (NM_011063.2) Inquiry
SHR067908 shRNA set against Rat Olr785_predicted(NM_001000603.1) Inquiry
Cat.No. Product Name Price
CDFR002903 Rat Pea15a cDNA Clone(NM_001013231.1) Inquiry
MiUTR1M-09092 PEA15A miRNA 3'UTR clone Inquiry
MiUTR1R-05751 PEA15A miRNA 3'UTR clone Inquiry
CDCL147931 Human Pea15a ORF clone (NM_011063.2) Inquiry
CDCR369989 Rat Pea15a ORF Clone(NM_001013231.1) Inquiry
Quick Inquiry