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PCDH3


Official Full Name
protocadherin beta cluster
Organism
Homo sapiens
Gene ID
56116
Background
The protocadherin beta cluster is one of three related gene clusters tandemly linked on chromosome five. The protocadherin genes have an immunoglobulin-like genomic organization, suggesting that a novel mechanism may be involved in their regulation and expression. The beta cluster contains 16 genes and 3 pseudogenes. Each gene product contains 6 extracellular cadherin domains and a cytoplasmic tail that diverges from other cadherin superfamily members. Unlike the alpha and gamma clusters, the beta cluster has a variable region but lacks a constant region. Without this downstream region of shared exons, each transcript encodes a unique cytoplasmic tail. The specific functions of these one-exon gene products are unknown; however, they are thought to play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
Synonyms
PCDHB@; PCDH3

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