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PAWR


Official Full Name
pro-apoptotic WT1 regulator
Organism
Homo sapiens
Gene ID
5074
Background
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Synonyms
PAR4; Par-4

Cat.No. Product Name Price
SHH371092 shRNA set against Human PAWR (NM_002583.2) Inquiry
SHH371096 shRNA set against Mouse PAWR (NM_054056.2) Inquiry
SHH371100 shRNA set against Rat PAWR (NM_033485.2) Inquiry
SHR089328 shRNA set against Rat Pawr(NM_033485.2) Inquiry
SHR089346 shRNA set against Mouse Pawr(NM_054056.2) Inquiry
SHR089364 shRNA set against Human PAWR(NM_002583.2) Inquiry
SHW007418 shRNA set against Danio rerio PAWR (NM_001006015) Inquiry
Cat.No. Product Name Price
CDFH013743 Human PAWR cDNA Clone(NM_002583.2) Inquiry
CDFH013744 Human PAWR cDNA Clone(NM_002583.2) Inquiry
CDFL009921 Mouse Pawr cDNA Clone(NM_054056.2) Inquiry
CDFR013024 Rat Pawr cDNA Clone(NM_033485.2) Inquiry
MiUTR1H-07534 PAWR miRNA 3'UTR clone Inquiry
MiUTR1M-08919 PAWR miRNA 3'UTR clone Inquiry
MiUTR1R-05634 PAWR miRNA 3'UTR clone Inquiry
CDCB168893 Danio rerio PAWR ORF Clone (NM_001006015) Inquiry
CDCB187698 Rabbit PAWR ORF clone (XM_008256842.1) Inquiry
CDCL146203 Human PAWR ORF clone (NM_002583.2) Inquiry
CDCL146205 Human Pawr ORF clone (NM_054056.2) Inquiry
CDCR380071 Rat Pawr ORF Clone(NM_033485.2) Inquiry
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