Pages
Products

PABPC4


Official Full Name
poly(A) binding protein cytoplasmic 4
Organism
Homo sapiens
Gene ID
8761
Background
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]
Synonyms
APP1; APP-1; PABP4; iPABP

Cat.No. Product Name Price
SHR077032 shRNA set against Mouse Pabpc4(NM_148917.2) Inquiry
SHH369780 shRNA set against Human PABPC4 (NM_003819.3) Inquiry
SHH369788 shRNA set against Rat PABPC4 (NM_001100538.1) Inquiry
SHR077042 shRNA set against Mouse Pabpc4(NM_130881.2) Inquiry
SHR077160 shRNA set against Mouse Pabpc4(NM_148917.2) Inquiry
SHR077168 shRNA set against Mouse Pabpc4(NM_130881.2) Inquiry
SHW017330 shRNA set against Danio rerio PABPC4 (NM_201296) Inquiry
Cat.No. Product Name Price
CDFH013582 Human PABPC4 cDNA Clone(NM_001135653.1) Inquiry
CDFH013583 Human PABPC4 cDNA Clone(NM_001135654.1) Inquiry
CDFR005092 Rat Pabpc4 cDNA Clone(NM_001100538.1) Inquiry
MiUTR1M-08850 PABPC4 miRNA 3'UTR clone Inquiry
MiUTR1M-08851 PABPC4 miRNA 3'UTR clone Inquiry
MiUTR3H-05942 PABPC4 miRNA 3'UTR clone Inquiry
MiUTR3H-05943 PABPC4 miRNA 3'UTR clone Inquiry
MiUTR3H-05944 PABPC4 miRNA 3'UTR clone Inquiry
CDCB178805 Danio rerio PABPC4 ORF Clone (NM_201296) Inquiry
CDCB193118 Rabbit PABPC4 ORF clone (XM_008265522.1) Inquiry
CDCL145447 Mouse PABPC4 ORF clone (NM_001135653.1) Inquiry
CDCL145449 Mouse PABPC4 ORF clone (NM_001135654.1) Inquiry
CDCL145451 Mouse Pabpc4 ORF clone (NM_130881.2) Inquiry
CDCL145453 Mouse Pabpc4 ORF clone (NM_148917.2) Inquiry
CDCR372313 Rat Pabpc4 ORF Clone(NM_001100538.1) Inquiry
CDCS408106 Human PABPC4 ORF Clone (BC065540) Inquiry
Quick Inquiry