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ptpn11a


Official Full Name
protein tyrosine phosphatase non-receptor type 11a
Organism
Danio rerio
Gene ID
333979
Background
Enables protein tyrosine phosphatase activity. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and neuromast hair cell development. Predicted to be active in cytoplasm. Is expressed in several structures, including blastoderm; blastomere; gill; immune system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
shp2; ptpn11; fa14b09; zgc:55388; wu:fa14b09; wu:fi24f03

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