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PTPN1


Official Full Name
protein tyrosine phosphatase non-receptor type 1
Organism
Homo sapiens
Gene ID
5770
Background
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Synonyms
PTP1B

Cat.No. Product Name Price
LV23072L human PTPN1 (NM_002827) lentivirus particles Inquiry
Cat.No. Product Name Price
SHR152148 shRNA set against Human PTPN1(NM_002827.2) Inquiry
SHW014451 shRNA set against Danio rerio PTPN1 (NM_130924) Inquiry
SHH386420 shRNA set against Human PTPN1 (NM_002827.2) Inquiry
SHH386424 shRNA set against Mouse PTPN1 (NM_011201.3) Inquiry
SHH386428 shRNA set against Rat PTPN1 (NM_012637.2) Inquiry
SHR152184 shRNA set against Rat Ptpn1(NM_012637.2) Inquiry
SHR152202 shRNA set against Mouse Ptpn1(NM_011201.3) Inquiry
SHW005381 shRNA set against Chicken PTPN1 (NM_204875) Inquiry
Cat.No. Product Name Price
CDFH015513 Human PTPN1 cDNA Clone(NM_002827.2) Inquiry
CDFR010455 Rat Ptpn1 cDNA Clone(NM_012637.2) Inquiry
MiUTR1H-08447 PTPN1 miRNA 3'UTR clone Inquiry
MiUTR1M-09754 PTPN1 miRNA 3'UTR clone Inquiry
MiUTR1R-06196 PTPN1 miRNA 3'UTR clone Inquiry
SKO0726 PTPN1 Validated sgRNA vector Inquiry
CDCB166856 Chicken PTPN1 ORF Clone (NM_204875) Inquiry
CDCB175926 Danio rerio PTPN1 ORF Clone (NM_130924) Inquiry
CDCB185032 Rabbit PTPN1 ORF clone (XM_008250441.1) Inquiry
CDCR250278 Mouse Ptpn1 ORF Clone(NM_011201.3) Inquiry
CDCR377502 Rat Ptpn1 ORF Clone(NM_012637.2) Inquiry
CDCS410995 Human PTPN1 ORF Clone (BC015660) Inquiry
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