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ptenb


Official Full Name
phosphatase and tensin homolog B
Organism
Danio rerio
Gene ID
368415
Background
Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic density. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
pten; fa11a08; fb73f10; fc83f12; fd16b10; fk90e11; wu:fa11a08; wu:fb73f10; wu:fc83f12; wu:fd16b10; wu:fk90e11; si:bz1g13.4

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