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PTBP1


Official Full Name
polypyrimidine tract binding protein 1
Organism
Homo sapiens
Gene ID
5725
Background
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Synonyms
PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I

Cat.No. Product Name Price
SHH385764 shRNA set against Mouse PTBP1 (NM_008956.2) Inquiry
SHH385768 shRNA set against Rat PTBP1 (NM_022516.5) Inquiry
SHR149582 shRNA set against Mouse Ptbp1(NM_001077363.1) Inquiry
SHR149610 shRNA set against Mouse Ptbp1(NM_008956.2) Inquiry
SHR149696 shRNA set against Mouse Ptbp1(NM_001077363.1) Inquiry
SHW001566 shRNA set against Chicken PTBP1 (NM_001030935) Inquiry
Cat.No. Product Name Price
CDCB163041 Chicken PTBP1 ORF Clone (NM_001030935) Inquiry
CDCH069316 Mouse Ptbp1 ORF clone (NM_008956.2) Inquiry
CDFL010991 Mouse Ptbp1 cDNA Clone(NM_008956.2) Inquiry
MiUTR1M-09718 PTBP1 miRNA 3'UTR clone Inquiry
MiUTR1M-09719 PTBP1 miRNA 3'UTR clone Inquiry
MiUTR3H-03560 PTBP1 miRNA 3'UTR clone Inquiry
MiUTR3H-03561 PTBP1 miRNA 3'UTR clone Inquiry
MiUTR3H-03562 PTBP1 miRNA 3'UTR clone Inquiry
CDCR233918 Mouse Ptbp1 ORF Clone(NM_001077363.1) Inquiry
CDCR379032 Rat Ptbp1 ORF Clone(NM_022516.5) Inquiry
CDCS410990 Human PTBP1 ORF Clone (BC004383) Inquiry
CDCS410991 Human PTBP1 ORF Clone (BC002397) Inquiry
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