Pages
Products

PSME3


Official Full Name
proteasome activator subunit 3
Organism
Homo sapiens
Gene ID
10197
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Synonyms
Ki; PA28G; HEL-S-283; PA28gamma; REG-GAMMA; PA28-gamma

Cat.No. Product Name Price
SHH385540 shRNA set against Human PSME3 (NM_176863.2) Inquiry
SHH385544 shRNA set against Mouse PSME3 (NM_011192.3) Inquiry
SHH385548 shRNA set against Rat PSME3 (NM_001011894.1) Inquiry
SHR148866 shRNA set against Mouse Psme3(NM_011192.3) Inquiry
SHR148884 shRNA set against Rat Psme3(NM_001011894.1) Inquiry
SHW000865 shRNA set against Chicken PSME3 (NM_001012550) Inquiry
SHW014839 shRNA set against Danio rerio PSME3 (NM_131376) Inquiry
Cat.No. Product Name Price
CDCH069196 human PSME3 ORF clone (NM_001267045.1) Inquiry
CDFR002326 Rat Psme3 cDNA Clone(NM_001011894.1) Inquiry
MiUTR1M-09711 PSME3 miRNA 3'UTR clone Inquiry
MiUTR1R-06160 PSME3 miRNA 3'UTR clone Inquiry
SKO0721 PSME3 Validated sgRNA vector Inquiry
CDCB158826 Human PSME3 ORF clone (BC001423) Inquiry
CDCB162340 Chicken PSME3 ORF Clone (NM_001012550) Inquiry
CDCB176314 Danio rerio PSME3 ORF Clone (NM_131376) Inquiry
CDCB186318 Rabbit PSME3 ORF clone (XM_002719410.2) Inquiry
CDCH069200 Mouse Psme3 ORF clone (NM_011192.3) Inquiry
CDCR369412 Rat Psme3 ORF Clone(NM_001011894.1) Inquiry
CDCS412418 Human PSME3 ORF Clone (BC001423) Inquiry
Quick Inquiry