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PSME2


Official Full Name
proteasome activator subunit 2
Organism
Homo sapiens
Gene ID
5721
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
Synonyms
PA28B; REGbeta; PA28beta

Cat.No. Product Name Price
SHH385532 shRNA set against Mouse PSME2 (NM_011190.3) Inquiry
SHH385536 shRNA set against Rat PSME2 (NM_017257.2) Inquiry
SHR148728 shRNA set against Rat Psme2(NM_017257.2) Inquiry
SHR148818 shRNA set against Mouse Psme2(NM_011190.3) Inquiry
SHR148836 shRNA set against Human PSME2(NM_002818.2) Inquiry
SHR148920 shRNA set against Mouse Psme2(NM_001029855.1) Inquiry
SHW014837 shRNA set against Danio rerio PSME2 (NM_131374) Inquiry
Cat.No. Product Name Price
SKO0720 PSME2 Validated sgRNA vector Inquiry
MiUTR1M-09710 PSME2 miRNA 3'UTR clone Inquiry
MiUTR1M-09709 PSME2 miRNA 3'UTR clone Inquiry
MiUTR1H-08395 PSME2 miRNA 3'UTR clone Inquiry
CDFR011307 Rat Psme2 cDNA Clone(NM_017257.2) Inquiry
CDFH015411 Human PSME2 cDNA Clone(NM_002818.2) Inquiry
CDFG017583 Mouse Psme2 cDNA Clone(NM_001029855.1) Inquiry
MiUTR1R-06159 PSME2 miRNA 3'UTR clone Inquiry
CDCS410989 Human PSME2 ORF Clone (BC072025) Inquiry
CDCR378321 Rat Psme2 ORF Clone(NM_017257.2) Inquiry
CDCR284142 Human PSME2 ORF Clone(NM_002818.2) Inquiry
CDCH069190 Mouse Psme2 ORF clone (NM_011190.3) Inquiry
CDCH069188 Mouse Psme2 ORF clone (NM_001029855.1) Inquiry
CDCB191224 Rabbit PSME2 ORF clone (XM_002718096.2) Inquiry
CDCB176312 Danio rerio PSME2 ORF Clone (NM_131374) Inquiry
CDCS410988 Human PSME2 ORF Clone (BC004368) Inquiry
CDCB158868 Human PSME2 ORF clone (BC004368) Inquiry
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