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PSME1


Official Full Name
proteasome activator subunit 1
Organism
Homo sapiens
Gene ID
5720
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Synonyms
PA28A; IFI5111; REGalpha; PA28alpha; HEL-S-129m

Cat.No. Product Name Price
SHH385516 shRNA set against Human PSME1 (NM_176783.1) Inquiry
SHH385520 shRNA set against Mouse PSME1 (NM_011189.1) Inquiry
SHH385524 shRNA set against Rat PSME1 (NM_017264.3) Inquiry
SHR148992 shRNA set against Mouse Psme1(NM_011189.1) Inquiry
SHR149010 shRNA set against Human PSME1(NM_176783.1) Inquiry
SHR149028 shRNA set against Human PSME1(NM_006263.2) Inquiry
SHW014838 shRNA set against Danio rerio PSME1 (NM_131375) Inquiry
Cat.No. Product Name Price
CDCB158854 Human PSME1 ORF clone (BC000352) Inquiry
CDFG011240 Human PSME1 cDNA Clone(NM_176783.1) Inquiry
CDFG011243 Human PSME1 cDNA Clone(NM_176783.1) Inquiry
CDFH015409 Human PSME1 cDNA Clone(NM_006263.2) Inquiry
CDFH015410 Human PSME1 cDNA Clone(NM_006263.2) Inquiry
MiUTR1H-08393 PSME1 miRNA 3'UTR clone Inquiry
MiUTR1H-08394 PSME1 miRNA 3'UTR clone Inquiry
MiUTR1M-09708 PSME1 miRNA 3'UTR clone Inquiry
SKO0719 PSME1 Validated sgRNA vector Inquiry
CDCB176313 Danio rerio PSME1 ORF Clone (NM_131375) Inquiry
CDCB191518 Rabbit PSME1 ORF clone (XM_008269418.1) Inquiry
CDCH069182 human PSME1 ORF clone (NM_176783.1) Inquiry
CDCH069184 Mouse Psme1 ORF clone (NM_011189.1) Inquiry
CDCR292466 Human PSME1 ORF Clone(NM_006263.2) Inquiry
CDCR378327 Rat Psme1 ORF Clone(NM_017264.3) Inquiry
CDCS412635 Human PSME1 ORF Clone (BC000352) Inquiry
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