Pages
Products

PSMC1


Official Full Name
proteasome 26S subunit, ATPase 1
Organism
Homo sapiens
Gene ID
5700
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
Synonyms
S4; p56; RPT2; P26S4; NEDGTH

Cat.No. Product Name Price
SHR147732 shRNA set against Rat Psmc1(NM_057123.1) Inquiry
SHH385268 shRNA set against Mouse PSMC1 (NM_008947.3) Inquiry
SHH385272 shRNA set against Rat PSMC1 (NM_057123.1) Inquiry
SHR147678 shRNA set against Mouse Psmc1(NM_008947.3) Inquiry
SHR147696 shRNA set against Human PSMC1(NM_002802.2) Inquiry
SHW005460 shRNA set against Chicken PSMC1 (NM_204958) Inquiry
Cat.No. Product Name Price
CDCS410972 Human PSMC1 ORF Clone (BC067741) Inquiry
CDFH015374 Human PSMC1 cDNA Clone(NM_002802.2) Inquiry
CDFR013734 Rat Psmc1 cDNA Clone(NM_057123.1) Inquiry
MiUTR1H-08384 PSMC1 miRNA 3'UTR clone Inquiry
MiUTR1M-09692 PSMC1 miRNA 3'UTR clone Inquiry
MiUTR1R-06146 PSMC1 miRNA 3'UTR clone Inquiry
CDCB166935 Chicken PSMC1 ORF Clone (NM_204958) Inquiry
CDCB187534 Rabbit PSMC1 ORF clone (XM_008271926.1) Inquiry
CDCR284097 Human PSMC1 ORF Clone(NM_002802.2) Inquiry
CDCR380767 Rat Psmc1 ORF Clone(NM_057123.1) Inquiry
CDCS410970 Human PSMC1 ORF Clone (BC016368) Inquiry
CDCS410971 Human PSMC1 ORF Clone (BC000512) Inquiry
Quick Inquiry