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PRUNE2


Official Full Name
prune homolog 2 with BCH domain
Organism
Homo sapiens
Gene ID
158471
Background
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Synonyms
BMCC1; BNIPXL; C9orf65; KIAA0367

Cat.No. Product Name Price
LV22870L human PRUNE2 (NM_015225) lentivirus particles Inquiry
Cat.No. Product Name Price
SHH384732 shRNA set against Human PRUNE2 (NM_015225.2) Inquiry
SHH384736 shRNA set against Mouse PRUNE2 (NM_181348.4) Inquiry
SHW012111 shRNA set against Danio rerio PRUNE2 (NM_001111154) Inquiry
Cat.No. Product Name Price
CDCB193670 Rabbit PRUNE2 ORF clone (XM_008256623.1) Inquiry
CDCR299120 Human PRUNE2 ORF Clone(NM_015225.2) Inquiry
CDFH015297 Human PRUNE2 cDNA Clone(NM_015225.2) Inquiry
CDFL010918 Mouse Prune2 cDNA Clone(NM_181348.4) Inquiry
MiUTR1H-05213 PRUNE2 miRNA 3'UTR clone Inquiry
CDCB173586 Danio rerio PRUNE2 ORF Clone (NM_001111154) Inquiry
CDCR275505 Mouse Prune2 ORF Clone(NM_181348.4) Inquiry
CDCS413905 Human PRUNE2 ORF Clone (BC019095) Inquiry
CDCS413906 Human PRUNE2 ORF Clone (BC022571) Inquiry
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