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PRKCH


Official Full Name
protein kinase C eta
Organism
Homo sapiens
Gene ID
5583
Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
Synonyms
PKCL; PKC-L; PRKCL; uORF2; nPKC-eta

Cat.No. Product Name Price
SHH382856 shRNA set against Mouse PRKCH (NM_008856.3) Inquiry
SHH382852 shRNA set against Human PRKCH (NM_006255.3) Inquiry
SHH382860 shRNA set against Rat PRKCH (NM_031085.2) Inquiry
SHR140460 shRNA set against Rat Prkch(NM_031085.2) Inquiry
SHR140478 shRNA set against Mouse Prkch(NM_008856.3) Inquiry
SHR140514 shRNA set against Human PRKCH(NM_006255.3) Inquiry
Cat.No. Product Name Price
CDFH015125 Human PRKCH cDNA Clone(NM_006255.3) Inquiry
CDFH015126 Human PRKCH cDNA Clone(NM_006255.3) Inquiry
CDFR012556 Rat Prkch cDNA Clone(NM_031085.2) Inquiry
MiUTR1H-08276 PRKCH miRNA 3'UTR clone Inquiry
MiUTR1M-09580 PRKCH miRNA 3'UTR clone Inquiry
MiUTR1R-06057 PRKCH miRNA 3'UTR clone Inquiry
CDCB160191 Human PRKCH ORF clone (BC001000) Inquiry
CDCB191217 Rabbit PRKCH ORF clone (XM_008271877.1) Inquiry
CDCH067846 Mouse Prkch ORF clone (NM_008856.3) Inquiry
CDCR292444 Human PRKCH ORF Clone(NM_006255.3) Inquiry
CDCR379578 Rat Prkch ORF Clone(NM_031085.2) Inquiry
CDCS412628 Human PRKCH ORF Clone (BC001000) Inquiry
CDCS412629 Human PRKCH ORF Clone (BC037268) Inquiry
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