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PRKACA


Official Full Name
protein kinase cAMP-activated catalytic subunit alpha
Organism
Homo sapiens
Gene ID
5566
Background
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Synonyms
CAFD1; PKACA; PPNAD4

Cat.No. Product Name Price
AD12876Z Human PRKACA adenoviral particles Inquiry
Cat.No. Product Name Price
SHH382672 shRNA set against Mouse PRKACA (NM_008854.4) Inquiry
SHH382676 shRNA set against Rat PRKACA (NM_001100922.1) Inquiry
SHR139560 shRNA set against Human PRKACA(NM_002730.3) Inquiry
SHR139638 shRNA set against Human PRKACA(NM_207518.1) Inquiry
Cat.No. Product Name Price
CDFG013880 Human PRKACA cDNA Clone(NM_207518.1) Inquiry
CDFH015095 Human PRKACA cDNA Clone(NM_002730.3) Inquiry
CDFR005388 Rat Prkaca cDNA Clone(NM_001100922.1) Inquiry
MiUTR1H-08258 PRKACA miRNA 3'UTR clone Inquiry
MiUTR1H-08259 PRKACA miRNA 3'UTR clone Inquiry
MiUTR1R-06047 PRKACA miRNA 3'UTR clone Inquiry
CDCB157173 Mouse PRKACA ORF clone (NM_008854.3) Inquiry
CDCB195602 Rabbit PRKACA ORF clone (NM_001082109.1) Inquiry
CDCH067734 human PRKACA ORF clone (NM_207518.1) Inquiry
CDCH395231 Mouse PRKACA ORF clone(NM_008854.4) Inquiry
CDCL185817 Human PRKACA ORF clone(NM_002730.3) Inquiry
CDCR372409 Rat Prkaca ORF Clone(NM_001100922.1) Inquiry
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