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PRG4


Official Full Name
proteoglycan 4
Organism
Homo sapiens
Gene ID
10216
Background
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Synonyms
MSF; SZP; CACP; HAPO; JCAP

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CDCH067640 human PRG4 ORF clone (NM_001127710.1) Inquiry
CDCH067638 human PRG4 ORF clone (NM_005807.3) Inquiry
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