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PRDM8


Official Full Name
PR/SET domain 8
Organism
Homo sapiens
Gene ID
56978
Background
This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Synonyms
PFM5; EPM10; KMT8D

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SHW018469 shRNA set against Danio rerio PRDM8 (NM_213410) Inquiry
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CDCB179944 Danio rerio PRDM8 ORF Clone (NM_213410) Inquiry
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CDCH067498 human PRDM8 ORF clone (NM_001099403.1) Inquiry
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