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PPM1A


Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1A
Organism
Homo sapiens
Gene ID
5494
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Synonyms
PP2CA; PP2Calpha; PP2C-ALPHA

Cat.No. Product Name Price
SHH380794 shRNA set against Rat PPM1A (NM_017038.1) Inquiry
SHH380784 shRNA set against Human PPM1A (NM_177952.2) Inquiry
SHH380788 shRNA set against Mouse PPM1A (NM_008910.3) Inquiry
SHR105754 shRNA set against Rat Ppm1a(NM_017038.1) Inquiry
SHR105790 shRNA set against Human PPM1A(NM_177952.2) Inquiry
Cat.No. Product Name Price
CDFG011421 Human PPM1A cDNA Clone(NM_177952.2) Inquiry
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MiUTR1H-08163 PPM1A miRNA 3'UTR clone Inquiry
MiUTR1R-05994 PPM1A miRNA 3'UTR clone Inquiry
CDCB157237 Mouse PPM1A ORF clone (NM_008910.2) Inquiry
CDCB180958 Rabbit PPM1A ORF clone (XM_008271817.1) Inquiry
CDCH066632 human PPM1A ORF clone (NM_177951.2) Inquiry
CDCH066634 human PPM1A ORF clone (NM_177952.2) Inquiry
CDCH394923 Mouse PPM1A ORF clone(NM_008910.3) Inquiry
CDCR378150 Rat Ppm1a ORF Clone(NM_017038.1) Inquiry
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