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PON3

Official Full Name
paraoxonase 3
Background
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Synonyms
PON3; paraoxonase 3; serum paraoxonase/lactonase 3; paraoxanase-3; arylesterase 3; im:6909654; zgc:112374

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