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POMC


Official Full Name
proopiomelanocortin
Organism
Homo sapiens
Gene ID
5443
Background
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
Synonyms
LPH; MSH; NPP; POC; ACTH; CLIP; OBAIRH

Cat.No. Product Name Price
SHH379717 shRNA set against Human POMC (NM_000939.2) Inquiry
SHH379720 shRNA set against Mouse POMC (NM_008895.3) Inquiry
SHH379724 shRNA set against Rat POMC (NM_139326.2) Inquiry
SHR128448 shRNA set against Mouse Pomc1(NM_008895.3) Inquiry
SHR128496 shRNA set against Human POMC(NM_000939.2) Inquiry
SHR128514 shRNA set against Rat Pomc(NM_139326.2) Inquiry
SHW001714 shRNA set against Chicken POMC (NM_001031098) Inquiry
SHW015505 shRNA set against Danio rerio POMCA (NM_181438) Inquiry
Cat.No. Product Name Price
MiUTR4H-TG06881 POMC miRNA 3'UTR clone Inquiry
MiUTR1M-09415 POMC miRNA 3'UTR clone Inquiry
MiUTR1H-08087 POMC miRNA 3'UTR clone Inquiry
CDFR014424 Rat Pomc cDNA Clone(NM_139326.2) Inquiry
CDFH014715 Human POMC cDNA Clone(NM_001035256.1) Inquiry
CDCG013400 Mouse POMC ORF clone(NM_008895.3) Inquiry
CDFH014714 Human POMC cDNA Clone(NM_000939.2) Inquiry
CDFH014713 Human POMC cDNA Clone(NM_000939.2) Inquiry
MiUTR1R-05960 POMC miRNA 3'UTR clone Inquiry
CDCR381471 Rat Pomc ORF Clone(NM_139326.2) Inquiry
CDCL185769 Human POMC ORF clone(NM_001035256.1) Inquiry
CDCB196754 Rabbit LOC103347804 ORF clone (XM_008254727.1) Inquiry
CDCB191062 Rabbit POMC ORF clone (XM_008254814.1) Inquiry
CDCB180492 Rabbit LPH ORF clone (NM_001101689.1) Inquiry
CDCB176980 Danio rerio POMCA ORF Clone (NM_181438) Inquiry
CDCR338035 Human POMC ORF Clone(NM_000939.2) Inquiry
CDCB163189 Chicken POMC ORF Clone (NM_001031098) Inquiry
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