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PMS1

Official Full Name
PMS1 homolog 1, mismatch repair system component
Organism
Homo sapiens
GeneID
5378
Background
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
Synonyms
MLH2; PMSL1; hPMS1; HNPCC3;

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