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PMEL


Official Full Name
premelanosome protein
Organism
Homo sapiens
Gene ID
6490
Background
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Synonyms
P1; SI; SIL; ME20; P100; SILV; HMB45; ME20M; gp100; HMB-45; ME20-M; PMEL17; D12S53E

Cat.No. Product Name Price
SHW005612 shRNA set against Chicken PMEL (NM_205112) Inquiry
SHH378348 shRNA set against Human PMEL (NM_006928.4) Inquiry
SHH378352 shRNA set against Mouse PMEL (NM_021882.4) Inquiry
SHH378356 shRNA set against Rat PMEL (NM_001108729.1) Inquiry
Cat.No. Product Name Price
CDCH065276 human PMEL ORF clone (NM_001200053.1) Inquiry
CDFR008317 Rat Pmel cDNA Clone(NM_001108729.1) Inquiry
MiUTR1M-10699 PMEL miRNA 3'UTR clone Inquiry
CDCB159767 Human PMEL ORF clone (BC001414) Inquiry
CDCB167087 Chicken PMEL ORF Clone (NM_205112) Inquiry
CDCB189326 Rabbit PMEL ORF clone (XM_002711060.2) Inquiry
CDCG003530 Human PMEL ORF clone(NM_006928.4) Inquiry
CDCG003532 Mouse PMEL ORF clone(NM_021882.4) Inquiry
CDCR375360 Rat Pmel ORF Clone(NM_001108729.1) Inquiry
CDCS419247 Human PMEL ORF Clone (BC001414) Inquiry
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