Pages
Products

PLN


Official Full Name
phospholamban
Organism
Homo sapiens
Gene ID
5350
Background
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Synonyms
PLB; CMD1P; CMH18

Cat.No. Product Name Price
SHH377964 shRNA set against Human PLN (NM_002667.3) Inquiry
SHR123008 shRNA set against Mouse Pln(NM_001141927.1) Inquiry
SHH377968 shRNA set against Mouse PLN (NM_023129.5) Inquiry
SHH377972 shRNA set against Rat PLN (NM_022707.2) Inquiry
SHW005904 shRNA set against Chicken PLN (NM_205410) Inquiry
SHW013833 shRNA set against Danio rerio PLN (NM_001201561) Inquiry
Cat.No. Product Name Price
CDCR237829 Mouse Pln ORF Clone(NM_001141927.1) Inquiry
MiUTR1M-09341 PLN miRNA 3'UTR clone Inquiry
MiUTR3H-01737 PLN miRNA 3'UTR clone Inquiry
CDCB167379 Chicken PLN ORF Clone (NM_205410) Inquiry
CDCB175308 Danio rerio PLN ORF Clone (NM_001201561) Inquiry
CDCB180217 Rabbit PLN ORF clone (NM_001082621.1) Inquiry
CDCR255814 Mouse Pln ORF Clone(NM_023129.5) Inquiry
CDCR379158 Rat Pln ORF Clone(NM_022707.2) Inquiry
CDCS410901 Human PLN ORF Clone (BC005269) Inquiry
Quick Inquiry