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PION


Official Full Name
gamma-secretase activating protein
Organism
Homo sapiens
Gene ID
54103
Background
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
Synonyms
GSAP; PION

Cat.No. Product Name Price
SHH375968 shRNA set against Human PION (NM_017439.3) Inquiry
SHH375972 shRNA set against Mouse PION (NM_175437.3) Inquiry
SHH375976 shRNA set against Rat PION (NM_001107845.1) Inquiry
Cat.No. Product Name Price
CDCB193700 Rabbit GSAP ORF clone (XM_008258312.1) Inquiry
CDFG000746 Human PION cDNA Clone(NM_017439.3) Inquiry
CDFL010311 Mouse Pion cDNA Clone(NM_175437.3) Inquiry
CDFR007496 Rat Pion cDNA Clone(NM_001107845.1) Inquiry
MiUTR1H-05835 PION miRNA 3'UTR clone Inquiry
MiUTR1M-00964 PION miRNA 3'UTR clone Inquiry
CDCH064006 human PION ORF clone (NM_017439.3) Inquiry
CDCH064010 Mouse Pion ORF clone (NM_175437.3) Inquiry
CDCR374519 Rat Pion ORF Clone(NM_001107845.1) Inquiry
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